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), which quickly estimates the Preliminary parameters for the selected types and employs the Levenberg–Marquardt algorithm to determine the parameter values. The best model was resolute using Akaike’s data criterion to be a evaluate of goodness of suit. The inhibition mode was confirmed by visual inspection of Lineweaver–Burk plots of enzyme kinetic details provided by Enzyme Kinetics program.
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Twelve metabolites of the synthetic cannabinoid, EAM-2201, had been tentatively recognized in human hepatocytes in vitro, As well as in human liver and urine specimens in vivo for the first time. There was a definite difference in metabolism profile between the in vitro and in vivo final results.
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